Marijuana May Live On A Handling For Alzheimer's Disease
A novel preclinical study indicates that THC, the active component inwards marijuana, may dull or stop the progression of Alzheimer's disease.
THC (Tetrahydrocannabinol) is the active ingrient inwards marijuana that produces a psychoactive reaction. THC is a naturally occurring chemic heart as well as mortal inwards the marijuana plant.
Baca Juga
Cancer patients bring used marijuana medicinally to honor relief from the pain, nausea, as well as loss of appetite that tin hold out caused yesteryear cancer treatments.
| Subscribe to the |
Marijuana chemical compound may offering handling for Alzheimer's disease
New preclinical study indicates THC may dull or stop progression of memory-robbing disease
- Extremely depression levels of the chemical compound inwards marijuana known every bit delta-9-tetrahydrocannabinol, or THC, may dull or stop the progression of Alzheimer's disease, a recent study from neuroscientists at the University of South Florida shows.
- Findings from the experiments, using a cellular model of Alzheimer's disease, were reported online inwards the Journal of Alzheimer's Disease.
- Researchers from the USF Health Byrd Alzheimer's Institute showed that extremely depression doses of THC trim back the production of amyloid beta, establish inwards a soluble shape inwards close aging brains, as well as foreclose abnormal accumulation of this poly peptide -- a procedure considered 1 of the pathological hallmarks evident early on inwards the memory-robbing disease.
- These depression concentrations of THC too selectively enhanced mitochondrial function, which is needed to assist provide energy, transmit signals, as well as keep a good for y'all brain.
"THC is known to hold out a strong antioxidant alongside neuroprotective properties, but this is the showtime study that the chemical compound remove affects Alzheimer's pathology yesteryear decreasing amyloid beta levels, inhibiting its aggregation, as well as enhancing mitochondrial function," said study Pb writer Chuanhai Cao, PhD as well as a neuroscientist at the Byrd Alzheimer's Institute as well as the USF College of Pharmacy.
"Decreased levels of amyloid beta agency less aggregation, which may protect against the progression of Alzheimer's disease. Since THC is a natural as well as relatively security amyloid inhibitor, THC or its analogs may assist us prepare an effective handling inwards the future."
- The researchers dot out that at the depression doses studied, the therapeutic benefits of THC look to prevail over the associated risks of THC toxicity as well as retentiveness impairment.
"While nosotros are withal far from a consensus, this study indicates that THC as well as THC-related compounds may hold out of therapeutic value inwards Alzheimer's disease," Nabar said. "Are nosotros advocating that people job illicit drugs to foreclose the disease? No. It's of import to continue inwards hear that but because a drug may hold out effective doesn't hateful it tin hold out safely used yesteryear anyone. However, these findings may Pb to the evolution of related compounds that are safe, legal, as well as useful inwards the handling of Alzheimer's disease."
- The body's ain arrangement of cannabinoid receptors interacts alongside naturally-occurring cannabinoid molecules, as well as these molecules component division similarly to the THC isolated from the cannabis (marijuana) plant.
"The dose as well as target population are critically of import for whatever drug, as well as thus careful monitoring as well as command of drug levels inwards the blood as well as arrangement are rattling of import for therapeutic use, peculiarly for a chemical compound such every bit THC," Dr. Cao said.Featured Articles
Article citation:
Chuanhai Cao, Yaqiong Li, Hui Liu, Ge Bai, Jonathan May, Xiaoyang Lin, Kyle Sutherland, Neel Nabar as well as Jianfeng Cai; "The Potential Therapeutic Effects of THC on Alzheimer's Disease," Journal of Alzheimer's Disease, DOI: 10.3233/JAD-140093.
USF Health
USF Health's mission is to envision as well as implement the time to come of health. It is the partnership of the USF Health Morsani College of Medicine, the College of Nursing, the College of Public Health, the College of Pharmacy, the School of Biomedical Sciences as well as the School of Physical Therapy as well as Rehabilitation Sciences; as well as the USF Physician's Group. For to a greater extent than information, visithttp://www.health.usf.edu
The (ARR) offers a searchable Knowledge Base that contains over 4,886 articles. Those article, every bit good every bit our featured articles, are offered complimentary of accuse to the entire Alzheimer's community via the ARR website.
