Info Factors That Bring Upward One's Hear Synaptic Strength
Factors that receive upwards one's heed synaptic strength
A. Presynaptic factors
- Availability of neurotransmitter
- Availability of precursor molecules
- Amount (or activity) of the rate-limiting enzyme inwards the pathway for neurotransmitter synthesis
- Axon final membrane potential
- Axon final Ca2+
- Activation of membrane receptors inwards presynaptic terminal
- Axo-axonic synapses
- Autoreceptors
- Other receptors
- Certain drugs as well as diseases, which human activity via the higher upwards mechanisms
B. Postsynaptic factors
- Immediate by history of electrical nation of postsynaptic membrane (e.g. excitation or inhibition from temporal or spatial summation)
- Effects of other neurotransmitters or neuromodulators acting on postsynaptic neuron
- Up- or down-regulation as well as desensitization of receptors
- Certain drugs as well as diseases
C. General factors
- Area of synaptic contact
- Enzymatic devastation of neurotransmitter
- Geometry of diffusion path
- Neurotransmitter re-uptake
Drugs that bind to a receptor as well as hit a answer like to the normal activation of that receptor are called agonists. Drugs that bind to the receptor but are unable to activate it as well as block it are called antagonists.
Reference: Widmaier EP, Raff H, Strang KT. Vander's Human Physiology: the mechanisms of trunk function. 12 ed.New York: McGraw-Hill International Edition; 2011.