Info Using Stalk Cells From Hip Replacements To Assistance Process Ageing Adults
The tissue usually discarded during routine hip replacements could last a rich novel beginning of adult stalk cells for usage inward regenerative medicine, UNSW-led inquiry has found.
With tens of thousands of hip replacement surgeries performed each year, this tissue could bring “profound implications” inward clinical use, the scientists say.
“In hip replacement surgery, the femoral caput together with purpose of the cervix are resected to arrange the cervix of the implant,” explains report leader Professor Melissa Knothe Tate, the Paul M Trainor Chair inward Biomedical Engineering at UNSW.
“Typically this tissue is discarded, all the same it may render an untapped beginning of autologous stalk cells for ageing adults who were born a generation likewise early on to produce goodness from banking of tissues similar umbilical cord blood at birth.”
The study, published inward the latest number of STEM CELLS Translational Medicine, was led yesteryear the UNSW Graduate School of Biomedical Engineering together with involved orthopaedic surgeon Dr Ulf Knothe of the Cleveland Clinic inward Cleveland, scientists from Ludwig Maximilians University inward Munich together with Case Western Reserve University inward Cleveland.
The researchers wanted to stimulate upwards one's postulate heed the feasibility of using the patient’s ain tissue removed during routine articulation replacement to potentially heal and/or repair failing organs together with to process diseases.
The squad collected periosteum derived stalk cells (PDCs) from patients amongst rheumatoid arthritis or osteoarthritis, ranging inward historic menstruum from thirty to 72 years, who had undergone articulation replacements. They compared them amongst commercial os marrow stalk cells derived from prenatal donors inward patients upwards to 72-years-old.
Based on the results, the PDCs exhibited “remarkable similarities” to the os marrow cells cultured nether identical laboratory conditions. They also showed “no meaning differences” inward their mightiness to differentiate into other cells due to the donor’s historic menstruum or illness state,” Professor Knothe Tate together with her squad said inward their paper.
“The usage of periosteum tissue that is discarded amongst the femoral cervix inward replacing the hip is highly novel, every bit it represents an unprecedented together with to appointment unstudied beginning of stalk cells from rheumatoid arthritis or osteoarthritis patients,” they said.
Dr Ulf Knothe, the leading clinician on the study, concluded: “Use of stalk cells from periosteum may opened upwards up unprecedented opportunities for the handling of illness together with tissue/organ failure inward a population of osteoarthritic patients born simply about 4 decades likewise early on to depository fiscal establishment their ain cord tissue or blood.”
The sum article, “Arthritic periosteal tissue from articulation replacement surgery: Influenza A virus subtype H5N1 novel, autologous beginning of stalk cells,” volition last available online subsequently the embargo lifts: http://www.stemcellstm.com.
Media contact for Professor Knothe Tate: Fiona MacDonald, UNSW Media Office, +61 (0) 403 664 438, fionajmacdonald@gmail.com. Images available addition to a greater extent than on Professor Knothe Tate.