Healthy Life - Fast-Growing In Addition To Interesting Drugs Of 2015
This write-up is based on around of the drugs mentioned inwards the white paper: Productive Innovation Index (PII) 2015, celebrating the overstep xxx pharmaceutical companies - most successful at bringing innovations to market. Idea Pharma has produced this white newspaper - this society www.ideapharma.com links amongst pharma companies to successfully accept novel pharma products to marketplace (Idea Pharma is a stage 2 player). Idea Pharma does travel from stage 2a, for strategic positioning, differentiation, value preposition, path to marketplace strategy together with and then on…In stage 2 stage of clinical trials, the molecule is tested on larger seat out of patients (100 to 300 nos.) for efficacy together with safety.
The productive excogitation index 2015 was topped yesteryear Johnson together with Johnson.
In 2015 in that location were interesting pharmaceutical products from Gilead together with J & J - that tasted marketing success:
1) Sovaldi (sofusbivir 400 mg cinema coated tablets), from Gilead: is a medication used to process hepatitis C viral infection. This effective handling helps cut down peginterferon handling (for treating hepatitis C viral infection) together with every bit good reduces chances of liver cancer. Sofusbivir (a nucleotide analogue drug) blocks hepatitis C virus’s deoxyribonucleic acid polymerase enzyme thus preventing hepatitis C virus from replicating inwards the body. Sovaldi sales inwards 2014 was 10.30 billion USD. (In the starting fourth dimension nine months of 2014, Sovaldi recorded sales of 8.30 billion USD).
2) Olysio (simeprivir) together with Sovriad (simeprivir) from Johnson together with Johnson (Jannsen Therapeutics division) (both are simeprivir 150 mg capsules): Olysio is an antiviral antihepatitis C virus drug: simeprivir. It is given orally, ane time – a – day, inwards combination amongst pegylated interferon together with ribavirin (another antiviral drug) for handling of chronic HCV (Hepatitis C Virus) infection. This antiviral regimen is given to genotype 1 infected patients amongst chronic decompensated liver disease, including cirrhosis. Simeprivir is an oral NS3/4A protease enzyme inhibitor (second generation protease inhibitor) (this enzyme is acquaint inwards hepatitis C virus, together with inhibiting this enzyme prevents the hepatitis virus from replicating inwards host cell). Olysio was launched inwards the terminate of 2013, together with inwards starting fourth dimension nine months of 2014 it recorded sales 1.60 billion USD sales. Sovriad (from Jannsen) is every bit good a build of simeprivir sodium 150 mg capsules together with is marketed inwards Japan.
3) Invokana (canagliflozin 100 mg together with 300 mg cinema coated tablets) from Johnson together with Johnson: is a first-in-class antidiabetic drug that inhibits a poly peptide inwards the kidneys called SGLT2 (sodium glucose co-transporter 2 molecule), this poly peptide reabsorbs the bulk of glucose filtered yesteryear kidneys. Thus, yesteryear inhibiting SGLT2, glucose is non reabsorbed, it goes out of the trunk through the urine.
4) Imbruvica (ibrutinib 140 mg capsules) from Johnson together with Johnson: is a targeted therapy anticancer drug used for handling of blood cancer (leukemia): where in that location is increased WBC count, eg., chronic lymphocytic leukemia (this drug attacks cancerous cells without damaging normal cells, hence, side effects are less, ibrutinib non called a chemotherapy drug, since most chemotherapy drugs travel on the uncomplicated regulation that cancer cells dissever together with multiply faster than normal cells, but around normal cells every bit good dissever fast, hence, side effects amongst chemotherapy drugs are more). Ibrutinib targets an enzyme called Brutons Tyrosine Kinase (BTK). This enzyme poly peptide molecule is required for multiplication of malignant or cancerous WBCs (White Blood Cells). By blocking BTK, the multiplication of such cancerous B lymphocytes (a type of WBCs) is reduced. In 2014, Imbruvica had sales of most 492 1000000 USD.
5) Zytiga (abiraterone acetate 250 mg tablets) from Johnson together with Johnson: This drug inhibits an enzyme called CYP17. Zytiga is given inwards combination amongst prednisone for treatment of resistant prostate cancer that has spread to other parts of the body. When abiraterone inhibits CYP17 (which manifests every bit 2 enzymes), androgen synthesis is inhibited, reducing levels of testosterone, epiandrosterone together with dihydrotestosterone. By reducing blood levels of testosterone, abiraterone helps inwards reducing size of prostate gland etc. 2012 sales of Zytiga was almost 1 billion USD (near block buster, at 931 1000000 USD).
6) Invega sustenna (paliperidone pamitate, extended unloose injectable suspension, for IM use; available inwards v strengths including 39 mg, 78 mg etc.; available eg., every bit pre-filled syringe of 1 ml containing equivalent to 100 mg of paliperidone) from Johnson together with Johnson: this is an atypical antipsychotic used inwards schizophrenia, together with every bit adjunct to antidepressants together with mood stabilizers). This long acting injectable antipsychotic is given ane time a month. In 2014, Invega sustenna generated USD 1.5 billion sales.
7) Rezolsta (fixed dose combination of darunavir 800 mg together with cobicistat 150 mg cinema coated tablets, pinkish oval shaped) from Johnson together with Johnson: This is described every bit the starting fourth dimension boosted protease inhibitor. Darunavir is a protease inhibitor (anti HIV) amongst expert security together with efficacy. Cobicistat is a pharmacokinetic enhancer. This makes darunavir slow to eat together with improves patient compliance. Cobicistat together with ritonavir both inhibit CYP3A4, an enzyme. The HIV is an intracellular parasite of the CD4 T helper lymphocytes. The protease enzyme produced yesteryear HIV helps inwards replication of the HIV within the CD4 T helper lymphocytes (a type of WBCs). Darunavir is an enzyme that inhibits this protease enzyme together with stops the replication of HIV. Cobistat inhibits CYP3A4, an enzyme inwards the liver, that breaksdown or metabolises darunavir. Hence, due to the cobistat action, darunavir stays inwards the trunk for a longer fourth dimension together with is to a greater extent than efficacious inwards lowering the viral charge of HIV. Prezista (single factor darunivir) had sales of 1.70 billion USD inwards 2013.
8) Zydelig (idelalisib 150 mg per cinema coated tablet) from Gilead: this is designated every bit breatkthrough designated drug launched yesteryear Gilead. This breakthrough anticancer medicine used to process 3 types of blood cancer is an oral Phosphatidylinositol 3-kinase inhibitor. The indications are chronic lymphocytic leukemia, follicular B jail cellular telephone non Hodgkin lymphoma together with pocket-sized lymphocytic lymphoma.
Breakthrough designation: On July 9, 2012 the Food together with Drug Administration Safety together with Innovation Act (FDASIA) was signed. FDASIA Section 902 provides for a novel designation - Breakthrough Therapy Designation.
Influenza A virus subtype H5N1 breakthrough therapy is a drug:
Ø intended lonely or inwards combination amongst ane or to a greater extent than other drugs to process a serious or life threatening affliction or status and
Ø preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing therapies on ane or to a greater extent than clinically meaning endpoints, such every bit substantial handling effects observed early on inwards clinical development.
If a drug is designated every bit breakthrough therapy, FDA volition expedite the evolution together with review of such drug. All requests for breakthrough therapy designation volition live on reviewed within sixty days of receipt, together with FDA volition either grant or deny the request.
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