Can A Odor Exam Predict Early On Stages Of Alzheimer’S Disease?

Researchers study that an odor identification examination may testify useful inwards predicting cognitive turn down too detecting early-stage Alzheimer’s disease.

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How to encourage a dementia patients to eat

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How to Get Answers To Your Questions About Alzheimer's too Dementia

Smell Test May Predict Early Stages of Alzheimer’s Disease

Researchers from Columbia University Medical Center (CUMC), New York State Psychiatric Institute, too NewYork-Presbyterian reported that an odor identification examination may testify useful inwards predicting cognitive turn down too detecting early-stage Alzheimer’s disease.

• Their ii studies advise that the University of Pennsylvania Smell Identification Test (UPSIT) may offering a practical, low-cost option to other tests.

In i study, researchers administered UPSIT to 397 older adults (average historic menses of lxxx years) without dementia from a multiethnic population inwards northern Manhattan.

Dementia Care

Each of the participants also had an MRI scan to mensurate the thickness of the entorhinal cortex—the start expanse of the encephalon to hold upwards affected yesteryear Alzheimer’s disease.

• Four years later, fifty participants 12.6 percent) had developed dementia too nearly xx pct had signs of cognitive decline.
• The researchers institute that depression UPSIT scores, only non entorhinal cortical thickness, were significantly associated amongst dementia too Alzheimer’s disease. (Low UPSIT scores dot decreased powerfulness to correctly lay odors.)

Low UPSIT scores, only non entorhinal cortical thickness, also predicted cognitive decline, although entorhinal cortical thickness was significantly associated amongst UPSIT scores inwards those who transitioned to dementia.

“Our question showed that odor identification impairment and, to a lesser degree, entorhinal cortical thickness were predictors of the transition to dementia.  “These findings back upwards odor identification equally an early on predictor too advise that impairment inwards odor identification may precede thinning inwards the entorhinal cortex inwards the early on clinical phase of Alzheimer’s disease.” - Seonjoo Lee, PhD, assistant professor of clinical biostatistics (in psychiatry) at Columbia.

Memory Care

In approximately other study, researchers from CUMC evaluated the usefulness of UPSIT too tests that mensurate the amount of amyloid inwards the encephalon (in higher amounts, the poly peptide forms plaques inwards the brains of those amongst Alzheimer’s disease) inwards predicting retentiveness decline.

• The researchers administered UPSIT too performed either beta amyloid PET scanning or analysis of cerebrospinal fluid inwards 84 older adults (median historic menses of 71 years). 

• Of these, 58 participants had mild cognitive impairment. The researchers followed the participants for at to the lowest degree half dozen months.

• At follow-up, 67 pct of the participants had signs of retentiveness decline. 

Testing positive for amyloid amongst either method, only non UPSIT score, predicted cognitive decline.

Memory Tests

However, participants amongst a grade of less than 35 were to a greater extent than than 3 times equally probable to possess got retentiveness turn down equally those amongst higher UPSIT scores.

“Our question suggests that both UPSIT grade too amyloid condition predict retentiveness decline.  Younger age, higher education, too shorter follow-up may explicate why UPSIT did non predict turn down equally strongly inwards this study equally inwards previous studies. Although to a greater extent than question is needed, odor identification testing, which is much less expensive too easier to administer than PET imaging or lumbar puncture, may testify to hold upwards a useful tool inwards helping physicians counsel patients who are concerned most their adventure of retentiveness loss.” - said William Kreisl, MD, Professor of Neurology (in the Taub Institute) too a neurologist at NewYork-Presbyterian/Columbia.

Current methods are entirely capable of clinically detecting Alzheimer’s illness inwards the after stages of its development, when meaning encephalon harm has already occurred. 

“Our study adds to the growing torso of evidence demonstrating the potential value of odor identification testing inwards the detection of early-stage Alzheimer’s disease,” said D.P. Devanand, MD, professor of psychiatry (in neurology too inwards the Gertrude H. Sergievsky Center) at CUMC too senior writer of both studies.

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“Predictive Utility of Entorhinal Cortex Thinning too Odor Identification Test for Transition to Dementia too Cognitive Decline inwards an Urban Community Population” yesteryear Seonjoo Lee, PhD, et al., was funded yesteryear the National Institute on Aging, grants K01AG051348, R01AG034189, R01AG037212, K99/R00AG042483, R01AG041795.

“Both Odor Identification too Amyloid Status Predict Memory Decline inwards Older Adults” yesteryear William Kreisl, MD, et al., was funded yesteryear the National Institute on Aging, grants R01AG17761 too R01AG041795.

Columbia University Medical Center is domicile to the largest medical question company inwards New York City too State too i of the largest faculty medical practices inwards the Northeast. For to a greater extent than information, see cumc.columbia.edu

The Taub Institute has been designated equally a Center of Excellence for Alzheimer’s Disease yesteryear the New York State Department of Health. For to a greater extent than information, see The Taub Institute at http://www.cumc.columbia.edu/dept/taub/.

New York State Psychiatric Institute (founded inwards 1896) too the Columbia University Department of Psychiatry possess got been closely affiliated since 1925.

NewYork-Presbyterian is i of the nation’s most comprehensive healthcare delivery networks, focused on providing innovative too compassionate aid to patients inwards the New York metropolitan expanse too throughout the globe.

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