Can Statins Forestall Dementia?
A study of nearly 58,000 patients flora that high ascendence statins had the strongest protective effects against dementia.
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High doses of statins forbid dementia inwards older people, according to question presented at the European Society of Cardiogists yesteryear Dr Tin-Tse Lin from Taiwan.
Baca Juga
The study of nearly 58,000 patients flora that high ascendence statins had the strongest protective effects against dementia.
“Statins are widely used inwards the older population to cut the jeopardy of cardiovascular disease. But recent reports of statin-associated cognitive harm possess got led the United States of America Food as well as Drug Administration (FDA) to listing statin-induced cognitive changes, especially for the older population, inwards its security communications.”
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High dose statins forbid dementia
The Gist
- Previous studies had considered statin therapy to exert a beneficial outcome on dementia. But few large-scale studies possess got focused on the deportment upon of statins on new-onset, non-vascular dementia inwards the geriatric population.
- The electrical flow study examined whether statin purpose was associated amongst novel diagnoses of dementia.
- The researchers used a random sample of 1 meg patients covered yesteryear Taiwan’s National Health Insurance.
- They identified 57,669 patients aged >65 years who had no history of dementia inwards 1997 as well as 1998.
- The analysis included pre-senile as well as senile dementia but excluded vascular dementia.
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The Highlights
- There were 5,516 novel diagnoses of dementia during some 4.5 years of follow-up.
- The remaining 52,153 patients aged >65 formed the command group.
- Subjects were divided into tertiles according to their hateful daily equivalent1 dosage as well as full (across the entire follow upwards period) equivalent dosage.
- The adjusted jeopardy ratios (HRs) for dementia were significantly inversely associated amongst increased daily or full equivalent statin dosage.
- The adjusted jeopardy ratios (HRs) for dementia were significantly inversely associated amongst increased daily or full equivalent statin dosage.
- The protective outcome of statins remained inwards unlike age, sex as well as cardiovascular jeopardy subgroups.
Dr Lin said: “The adjusted risks for dementia were significantly inversely associated amongst increased full or daily equivalent statin dosage. Patients who received the highest full equivalent doses of statins had a 3-fold decrease inwards the jeopardy of developing dementia. Similar results were flora amongst the daily equivalent statin dosage.”
The Findings
- It was the ascendence of the statins rather than their solubility (lipophilic or hydrophilic) which was a major determinant inwards reducing dementia.
- High ascendence statins such every bit atorvastatin as well as rosuvastatin showed a meaning inverse association amongst developing dementia inwards a dose-response manner.
- Higher doses of high ascendence statins gave the strongest protective effects against dementia.
- The results were consistent when analysing daily doses of unlike kinds of statins.
- Almost all the statins (except lovastatin) decreased the jeopardy for novel onslaught dementia when taken at higher daily doses.
- A high hateful daily dosage of lovastatin was positively associated amongst the evolution of dementia, perchance because lovastatin is a lipophilic statin acre the anti-inflammatory cholesterol lowering outcome of lovastatin is non comparable to that of atorvastatin as well as simvastatin.
- To the best of our knowledge, this was the showtime large-scale, nation-wide study which examined the outcome of unlike statins on novel onslaught dementia (except vascular dementia) inwards an elderly population.
- The investigators flora that high doses of statins, peculiarly high ascendence statins, forbid dementia.
The European Society of Cardiology (ESC) represents to a greater extent than than eighty 000 cardiology professionals across Europe as well as the Mediterranean. Its mission is to cut the burden of cardiovascular illness inwards Europe.
http://www.escardio.org/about/press/press-releases/esc13-amsterdam/Pages/statins-dementia-elderly.aspx
Original content +Bob DeMarco .
