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Alzheimer's Cistron Written Report Launched Past Times Ny Genome Center, Illumina, Feinstein

Up to 1,000 Genomes to hold upwardly Sequenced over Four Years inwards Search of Susceptibility Genes Associated with Alzheimer's Disease inwards Patients



New York Genome Center (NYGC), inwards collaboration with Illumina, today announced at the Advances inwards Genome Biology together with Technology (AGBT) annual coming together the initiation of a large-scale whole genome sequencing projection with the Feinstein Institute for Medical Research.

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NYGC is a public-private coalition of universities, medical centers, engineering partners, pharmaceutical companies together with private philanthropists that are engaged inwards a cooperative endeavour to transform medical interrogation together with clinical care.

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New York Genome Center Launches Major Initiative with the Feinstein Institute for Medical Research to Sequence Whole Genomes of Alzheimer’s Patients

The overarching finish of this projection is to sympathize the genetic solid soil of susceptibility to Alzheimer's disease, of which rattling lilliputian is currently known. Knowledge of genetic susceptibility volition assist to assess an individual's lifetime gamble of developing the disease, together with improve define the molecular pathways responsible for neuronal degeneration. Understanding the molecular solid soil of neuronal degeneration volition permit scientists to prepare effective strategies for early on detection together with targeted treatment.

Whole genome sequencing efforts volition start out with 130 Alzheimer's patient samples, for whom in that location is detailed clinical information together with encephalon pathology available. Over a four-year period, upwardly to 1,000 genomes of patients with Alzheimer's affliction volition hold upwardly sequenced together with compared to the genomes of a command grouping of elderly individuals. All information resulting from this projection volition hold upwardly made freely available to the scientific community.

"This exciting endeavor is a groovy illustration of the collaborative potential of New York Genome Center, working amongst our Institutional Founding Members together with a engineering leader similar Illumina," said Nancy J. Kelley, JD, MPP, Founding Executive Director of the New York Genome Center. "The Feinstein Institute's commitment to sharing the information resulting from these efforts with the greater interrogation community could significantly accelerate the speed of translational interrogation inwards Alzheimer's disease, with a profound affect on patient attention together with clinical outcomes, which is inwards trouble with the vision of NYGC."

The genome sequencing, bioinformatics together with information storage services beingness made available to NYGC volition enable the Feinstein Institute together with other NYGC fellow member institutions to consummate large scale genomic interrogation projects, utilizing the latest engineering together with nearly advanced analytical expertise. Together, NYGC together with Illumina are committed to transforming the electrical current interrogation model into a fully integrated partnership of leading academic centers together with marketplace position leaders inwards pharma sequencing technology.

"This projection is a massive task that involves sequencing thirty billion bases per individual for 1,000 patient samples together with thence comparison these sequences to normal individuals," said Peter Davies, PhD, scientific managing director of the Feinstein Institute's Litwin-Zucker Center for Research on Alzheimer's Disease. "NYGC provides us with the sequencing expertise together with information analysis capability that are required for such a large scale endeavor."

This projection is beingness funded through a grant yesteryear private philanthropists Frank together with Mildred Feinberg of Locust Valley, NY, together with their family, inwards retentiveness of Mrs. Feinberg's mother, Esther Corman, who succumbed to Alzheimer's disease. physician Davies, who has been involved inwards interrogation on Alzheimer's affliction for to a greater extent than than 35 years, volition straight the Feinberg Initiative to sequence the genomes of 1,000 Alzheimer's affliction patients over the side yesteryear side 4 years.

"The launch of this initiatory with NYGC together with The Feinstein Institute volition enable a deeper agreement of the clinical application of genetics, along the path of improving human health," said Jay Flatley, Illumina's President together with CEO. "We're confident that Illumina's collaboration with NYGC volition play a major role inwards enabling Feinstein's success inwards achieving its goals toward agreement the genetic solid soil of susceptibility for Alzheimer's disease."

As component of the novel collaboration betwixt NYGC together with Illumina, NYGC volition furnish Illumina with access to its Institutional Founding Members, who stand upwardly for hundreds of academic together with medical experts together with multiple affliction focuses. Illumina volition furnish NYGC with early on access to primal novel products, its long rail tape of excogitation together with its manufacture leading expertise.

"This side yesteryear side stage inwards our collaboration with the New York Genome Center is an chance to practise novel bioinformatic channels together with solutions, spell integrating interrogation into translational medicine," said Matt Posard, Senior Vice President together with General Manager of Illumina's Translational together with Consumer Genomics Business.

Founded inwards August, 2010, NYGC is a public-private coalition of universities, medical centers, engineering partners, pharmaceutical companies together with private philanthropists that are engaged inwards a cooperative endeavour to transform medical interrogation together with clinical care.

NYGC intends to perish 1 of the largest genomic facilities inwards North America, establishing an unprecedented, starting fourth dimension of its kind, large scale collaborative venture inwards genomic medicine.

NYGC's Institutional Founding Members include Cold Spring Harbor Laboratory, Columbia University, Cornell University/Weill Cornell Medical College, The Jackson Laboratory, Memorial Sloan-Kettering Cancer Center, Mount Sinai Medical Center, New York-Presbyterian Hospital, New York University/NYU School of Medicine, North Shore-LIJ Health System, The Rockefeller University, together with Stony Brook University. The Hospital for Special Surgery is an Associate Founding Member.

About the New York Genome Center

New York Genome Center (NYGC) is an independent, non-profit arrangement -- leveraging the collaborative resources of leading academic medical centers, interrogation universities, together with commercial organizations. Our vision is to transform medical interrogation together with clinical attention inwards New York through the creation of 1 of the largest genomics together with bioinformatics facilities inwards North America.


New York Genome Center

About Illumina

Illumina ( www.illumina.com ) is a leading developer, manufacturer, together with marketer of life scientific discipline tools together with integrated systems for the analysis of genetic variation together with function.

About Peter Davies, Ph.D., together with The Feinstein Institute for Medical Research

Peter Davies, PhD, has been involved inwards interrogation on Alzheimer's affliction for to a greater extent than than 35 years. He is currently Scientific Director of the Litwin-Zucker Center for Research on Alzheimer's Disease at The Feinstein Institute for Medical Research, North Shore-LIJ. He also holds the Judith together with Burton P. Resnick Chair inwards Alzheimer's Disease Research at Albert Einstein College of Medicine.

For to a greater extent than information: www.FeinsteinInstitute.org

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