Resveratrol Clinical Case For Alzheimer's Forthwith Recruiting Novel Participants
Resveratrol is derived from plants as well as is institute inward highest levels inward ruby-red vino as well as the pare of ruby-red grapes. The Copenhagen City Heart Study (Treutlen et al 2002) reported that monthly as well as weekly consumption of ruby-red vino is associated amongst a lower peril of dementia.
Baca Juga
Resveratrol is derived from plants as well as is institute inward its highest concentration inward ruby-red vino as well as the pare of ruby-red grapes.
There is compelling evidence that caloric restriction tin give the axe better overall wellness yesteryear activating a degree of enzymes known equally Sirtuins.
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RESVERATROL IN ALZHEIMER’S DISEASE STUDY
Influenza A virus subtype H5N1 Phase II clinical study of Resveratrol (RES) designed to evaluate the safety, tolerability as well as effectiveness of Resveratrol on cerebrospinal fluid (CSF) as well as other biomarkers for the handling of Alzheimer's illness (AD).
Resveratrol is derived from plants as well as is institute inward highest levels inward ruby-red vino as well as the pare of ruby-red grapes. The Copenhagen City Heart Study (Treutlen et al 2002) reported that monthly as well as weekly consumption of ruby-red vino is associated amongst a lower peril of dementia. There is compelling evidence that caloric restriction tin give the axe better overall wellness yesteryear activating a degree of enzymes known equally Sirtuins. Resveratrol is a marrow institute inward some plants that straight activates sirtuins, mimicking the effects of caloric restriction as well as may impact regulatory pathways of diseases of aging, including AD.
In this study, people amongst AD volition last given either Resveratrol or placebo (looks similar the study drug only contains no active medication) for 12 months to decide whether daily Resveratrol therapy is beneficial inward delaying or altering the deterioration of retentivity as well as daily functioning. Patients amongst a diagnosis of in all likelihood AD may qualify for participation inward this study.
Patients that are eligible as well as handgrip to participate volition last amid 120 people enrolled inward the study. The RES study is taking house at almost 26 sites across the the States affiliated amongst the Alzheimer’s Disease Cooperative Study. Each query site volition enroll or then v participants. Participants who are already beingness treated for AD tin give the axe locomote along on their FDA-approved AD treatments (must last on a stable dose for a minimum of 3 months prior to screening for the study). Participants cannot last enrolled inward some other clinical study during this time. Patient participation volition end upwardly to 12 months as well as volition require upwardly to 10 study visits. Some of these visits may last performed over multiple days. This is a double-blind, placebo-controlled study which agency that study participants stimulate got a 50/50 gamble of receiving either Resveratrol or the placebo as well as neither the site or the player volition know if they are receiving placebo or Resveratrol.
Influenza A virus subtype H5N1 pocket-size grouping of xv participants volition last asked to convey part inward a to a greater extent than detailed 24-hour PK analysis sub-study that volition mensurate Resveratrol levels at xv unlike fourth dimension points over a 24 hr catamenia at v unlike visits..
The U.S. Food as well as Drug Administration (FDA) has non approved Resveratrol for the handling of AD as well as nosotros create non know whether the exercise of Resveratrol tin give the axe modify the course of study the disease.
To last eligible for this study participants must:
- Have a diagnosis of in all likelihood mild-to-moderate AD
- Age greater or equal to 50
- Be inward expert full general health
- Are fluent inward English linguistic communication or Spanish
- Are willing as well as able to undergo in-clinic assessments, ii lumbar punctures to assemble cerebral spinal fluid (CSF), 3 MRIs, as well as blood as well as urine tests.ave a reliable study partner that tin give the axe accompany the player to all study visits as well as has to a greater extent than than ii days a calendar week of contact amongst the participant.
- Able to abstain from ingesting large quantities of Resveratrol-containing foods, including ruby-red vino (one or ii spectacles of ruby-red vino or ruby-red grape juice or 1 serving of ruby-red grapes daily is acceptable).
- Able to abstain from ingesting herbal/natural preparations or dietary supplements containing Resveratrol.
Any of the next volition exclude participation:
- Significant neurological illness other than AD
- Depression, major psychiatric disorders as well as behavioral problems
- Alcohol or marrow abuse inside the end ii years
- History of cancer inside v years prior to screening (history of pare melanoma or stable prostate cancer are non excluded)
- Any pregnant systemic illness or unstable medical condition
- Participants volition last screened at the query sites to decide if they are eligible for the study.
To larn how to participate contact the NIA's Alzheimer's Disease Education as well as Referral (ADEAR) Center at 1-800-438-4380 or yesteryear e-mail to adear@nia.nih.gov.
Or, for lead contact
| BannerHealth Alzheimer’s Institute | AZ | 602-839-6279 |
| University of California Irvine | CA | 949-824-8726 |
| University of California San Diego | CA | 858-246-1306 |
| University of Southern California | CA | 323-442-7594 |
| Yale University | CT | 203-764-8100 |
| USF Health Byrd Alzheimer’s Institute | FL | 813-974-4355 |
| Mayo Clinic, Jacksonville | FL | 904-953-8035 |
| Rush University Memory Clinic | IL | 312-563-4111 |
| University of Kansas | KS | 913-945-5033 |
| University of Kentucky | KY | 859-323-1331 |
| Johns Hopkins | MD | 410-550-9022 |
| University of Michigan | MI | 734-647-7760 |
| Mayo Clinic, Rochester | MN | 507-293-4711 |
| Cleveland Clinic Lou Ruvo Center | NV | 702-483-6026 |
| Columbia University | NY | 212-305-7661 |
| Mount Sinai School of Medicine | NY | 646-284-7547 |
| New York University Med Center | NY | 212-263-5708 |
| University of Rochester | NY | 585-760-6562 |
| Case Western Reserve University | OH | 216-464-6467 |
| University of Pennsylvania | PA | 215-615-3084 |
| Medical University of South Carolina | SC | 843-740-1592 ext. 40 |
| Baylor College of Medicine | TX | 713-798-5325 |
| University of Texas, SWMC | TX | 214-648-9376 |
| University of Washington | WA | 206-764-2339 |
| Georgetown University | DC | 202-687-0413 |
| Howard University | DC | 202-865-3776 |
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Original content Bob DeMarco, the