Are Still Seizures A Symptom Of Alzheimer's Disease?
While I was taking attention of my mom, Dotty, I ofttimes worried most seizures. Silent Seizures.
My woman raise ofttimes suffered from severe headaches peculiarly inwards the morning. This was an ongoing work that would come upward as well as go. The enquiry below indicates that the soundless seizures occurred while patients were sleeping..
I genuinely received preparation on what to await for, as well as the signs as well as symptoms of seizures.
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By Bob DeMarco
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I also worried most soundless seizures because they tin introduce every bit a shape of confusion. Alzheimer's patients ofttimes introduce signs of confusion.
Researchers are showtime to suspect that treating these seizures could assist care Alzheimer's or mayhap ho-hum it down.
Silent seizures recorded inwards the hippocampus of ii patients alongside Alzheimer's disease
Seizure-like activity inwards substitution retentiveness construction may contribute to cognitive symptoms, offering novel therapeutic target
- Massachusetts General Hospital (MGH) investigators have got identified silent, seizure-like activity inwards the hippocampus – a encephalon construction significantly affected inwards Alzheimer’s disease.
These alterations inwards the brain’s electrical activity could non survive detected past times measure EEG readings taken on the scalp as well as primarily occurred during sleep, a fourth dimension when the preceding day’s memories are consolidated.
“While it is non surprising to discover dysfunction inwards encephalon networks inwards Alzheimer’s disease, our novel finding that networks involved inwards retentiveness business office tin travel silently epileptic could Pb to opportunities to target that dysfunction alongside novel or existing drugs to cut back symptoms or potentially alter the course of pedagogy of the disease.”
“We at nowadays have got to study to a greater extent than individuals to validate this finding as well as sympathise how prevalent it is inwards Alzheimer’s patients, whether it occurs inwards other neurodegenerative disorders as well as how it responds to treatment.” Andrew Cole, MD, manager of the MGH Epilepsy Service as well as senior writer of the Nature Medicine paper.
- The investigators depict ii patients – both women inwards their 60s – who had developed symptoms suggestive of Alzheimer’s disease, such every bit confusion as well as repeatedly shout out for the same questions.
- Brain imaging studies as well as cerebrospinal fluid analysis for both patients were consistent alongside Alzheimer’s disease.
- It is mutual for patients alongside Alzheimer’s to sense fluctuations inwards their symptoms, but inwards both of these patients, those fluctuations were to a greater extent than exaggerated than typically seen.
While scalp EEG recordings did non give away seizure-like activity, the investigators suspected that there may survive undetected seizures inside the hippocampus – a substitution construction affected past times Alzheimer’s illness that is critical for retentiveness consolidation as well as is a mutual source of seizures inwards people alongside epilepsy.
They decided to elbow grease a to a greater extent than straight way of monitoring electrical activity inwards the hippocampus as well as related structures.
Electrodes were placed side past times side to those structures on both sides of the brain through the foramen ovale (FO), naturally occurring openings at the base of operations of the skull. Each patients’ encephalon activity was monitored simultaneously alongside both implanted electrodes as well as alongside scalp EEG for 24 to 72 hours.
In i patient, the FO electrodes revealed frequent bursts of electrical activity called spikes, often associated alongside seizures, most which were non detectable past times scalp EEG.
- During a 12-hour catamenia she experienced three seizures, all taking identify during slumber but non producing whatsoever visible symptoms.
FO electrode recording inwards the other patient also revealed frequent spiking during sleep, but anti-seizure handling had to survive discontinued because of adverse effects on her mood.
“Our findings confirmed the presence of serious dysfunction of the neuronal networks affected past times Alzheimer’s illness as well as confirmed our hypothesis that epileptic phenomena are an of import element of that disturbance,” says Cole, who is a professor of Neurology at Harvard Medical School. “Additional recordings alongside FO electrodes inwards patients alongside Alzheimer’s illness volition assist us develop amend tools based on computerized analysis of EEG signals as well as mayhap functional neuroimaging studies to ascertain how mutual soundless seizures are inwards Alzheimer’s disease without the demand for the minimally invasive electrodes nosotros used inwards these patients.”
The written report appeared inwards the online publication inwards Nature Medicine.
Influenza A virus subtype H5N1 recent study led past times Alice Lam, MD, PhD, also of the MGH Epilepsy Service as well as Pb writer of the electrical flow study demonstrated a novel tool for detecting hippocampal seizures non detectable by scalp EEGs inwards patients alongside epilepsy.
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Cole adds, as well as his squad is working to refine this tool as well as apply it to Alzheimer’s disease. Since in that location also is show that higher levels of neuronal activity tin increment the production as well as deposition of Alzheimer’s associated proteins such every bit tau as well as amyloid-beta, agreement whether seizure-like activity accelerates the progression of Alzheimer’s illness volition survive a high priority for their team.
Atypical (a-TIP-i-kul) seizure agency odd or non typical. The individual volition stare (as they would inwards whatsoever absence seizure) but ofttimes is somewhat responsive. Eye blinking or slight jerking movements of the lips may occur. Epilepsy Foundation
What Are the Symptoms of an Absence Seizure?
Because absence seizures are unremarkably quite brief, tend to arrive at during times of inactivity, as well as closely resemble daydreaming or "being off inwards one's ain world," they may exceed unnoticed past times others as well as travel undiagnosed for or thence time.
Absence seizures autumn into ii categories: typical as well as atypical.
WebMD
Undetected or "silent" seizures may contribute to or thence symptoms associated alongside Alzheimer's disease, such every bit confusion.
The seizures occur inwards the hippocampus -- a part of the encephalon involved inwards the consolidation of memories. Researchers suspect that treating these seizures could assist care Alzheimer's or mayhap ho-hum it down.
WebMD
Additional co-authors of the Nature Medicine newspaper are Gina Deck, MD, MGH Epilepsy Service; Emad Eskandar, MD, MGH Department of Neurosurgery; as well as Alicia Goldman, MD, PhD, as well as Jeffrey Noebels, MD, PhD, Baylor College of Medicine. Support for the study includes National Institute of Neurological Disorders as well as Stroke grants R25-NS065743, U01-NS090362, as well as R01-NS029709; as well as grants from Citizens United for Research inwards Epilepsy as well as the Blue Bird Circle Foundation.
Massachusetts General Hospital, founded inwards 1811, is the master copy as well as largest teaching infirmary of Harvard Medical School.
Seizures are a sign of encephalon injury as well as are caused past times precipitous disorganized electrical activity inwards the brain. Seizures tin survive characterized past times spasms or convulsions.
Alzheimer illness (AD) as well as epilepsy are disorders commonly seen inwards the elderly. Many studies have got shown that patients alongside AD are at increased conduct a opportunity for developing seizures as well as epilepsy.
Transient symptoms inwards Alzheimer illness (AD) are frequent as well as include seizures, syncope, as well as episodes of inattention or confusion.
Undetected or "silent" seizures may contribute to or thence symptoms associated alongside Alzheimer's disease, such every bit confusion.
The principal underlying drive of retentiveness loss as well as confusion is the progressive harm to encephalon cells caused past times Alzheimer's disease.
