Effects Of Antioxidants For Alzheimer Disease

The combination of vitamin E, vitamin C, in addition to alpha-lipoic acid did non lower levels of the amyloid in addition to tau proteins that brand upwards the plaques in addition to tangles seen inward the encephalon amongst Alzheimer's disease.

Researchers convey suggested that antioxidants mightiness assist thwart Alzheimer's disease, but this novel report finds that a "cocktail" of vitamins E, vitamin C in addition to alpha-lipoic acid has no consequence on for sure indicators of the encephalon disorder.

The supplements may fifty-fifty convey hastened mental decline, the researchers said.

"Many, many people are taking these kinds of supplements amongst actually really picayune scientific justification," said medico Ronald Petersen, caput of the Mayo Alzheimer's Disease Research Center inward Rochester, Minnesota.

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Clinical Trial Examining Effects of Antioxidants for Alzheimer Disease on Cerebrospinal Fluid Biomarkers

An antioxidant combination of vitamin E, vitamin C in addition to α-lipoic acid (E/C/ALA) was non associated amongst changes inward but about cerebrospinal fluid biomarkers related to Alzheimer affliction inward a randomized controlled trial, according to a report published Online First past times Archives of Neurology.

Oxidative harm inward the encephalon is associated amongst aging in addition to is widespread inward Alzheimer affliction (AD) patients. Some observational studies convey suggested that an antioxidant-rich diet may bring down the lead a opportunity of AD, but antioxidant randomized clinical trials inward AD convey had mixed results, the authors write inward their report background.

Douglas R. Galasko, M.D., of the University of California, San Diego, in addition to colleagues examined changes inward cerebrospinal fluid (CSF) biomarkers related to Alzheimer affliction in addition to oxidative stress, noesis in addition to function.

The report included 78 patients from the Alzheimer’s Disease Cooperative Study (ADCS) Antioxidant Biomarker report who were divided into i of 3 groups:

• 800 IU/per 24-hour interval of vitamin due east (α-tocopherol) addition 500 mg/per 24-hour interval of vitamin C addition 900 mg/per 24-hour interval of α-lipoic acid (E/C/ALA); 
• 400 mg of coenzyme Q (CoQ) 3 times a day;
•  or placebo.

Sixty-six patients provided series CSF specimens adequate for biochemical analyses during the 16-week trial.

“The combination of E/C/ALA did non touching on CSF biomarkers related to Αβ, tau or P-tau (which are related to AD),” the authors comment.

The E/C/ALA grouping did encounter a lowering of CSF F2-isoprostane levels suggesting a reduction of oxidative stress inward the brain, the results indicate. However, the handling raised caution close faster cognitive reject every bit assessed past times the Mini-Mental State Examination (MMSE).

“It is unclear whether the relatively pocket-size reduction inward CSF F2-isoprostane degree seen inward this report may Pb to clinical benefits inward AD. The to a greater extent than rapid MMSE score reject raises a caution in addition to indicates that cognitive functioning would demand to survive assessed if a longer-term clinical case of this antioxidant combination is considered,” the authors conclude.

The authors too banking company annotation the results betoken that spell CoQ was rubber in addition to good tolerated inward patients, the absence of a biomarker signal inward CSF suggests that CoQ, at the tested dose, does non amend indices of oxidative stress or neurodegeneration.

“These results produce non back upwards farther clinical case evolution of CoQ inward AD,” the researchers conclude.

(Arch Neurol. doi:10.1001/archneurol.2012.85).

*This piece of employment was supported past times a National Institute on Aging grant.

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