Is Bexarotene A Magical Cure For Alzheimer's, Or A Magic Eraser
I admit, I am tempted to purchase Bexarotene off-label for my mother, Dotty. What is the risk? She is almost 96 years old, in addition to inward an advanced phase of Alzheimer's. On the other hand, I must inquire myself, what are the consequences if I impairment or kill her? Those consequences aside, would I travel able to alive amongst myself if I harmed her?
Lets showtime amongst the sum disclosure. I am non a Dr. or a scientist. The opinions stated hither are my own, in addition to based on data that is currently available to me.
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This calendar week the Alzheimer's community is buzzing close a novel enquiry written report published inward Science Express that indicates amyloid plaque (Abeta) was removed from Alzheimer's infected mice inward a few hours past times an already existing, FDA approved drug, Bexarotene.
The immediate question, tin you lot purchase the drug off label? The uncomplicated answer is yes. All you lot demand is a Dr. that is willing to write the prescription.
I already know from the emails I am receiving, in addition to from the responses of scientists, doctors, in addition to neurologists, that people are quest for the drug.
Bexarotene is expensive in addition to terms almost $1200.00 for 30, 75 mg capsules.
Do I think that to a greater extent than or less members of the Alzheimer's community volition endeavour this medication, off label, for the handling of Alzheimer's? My sense tells me that the answer is, Yes.
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I am at i time remembering a frenzy that was started inward the 1990s when Shark's molar (cartilage) was beingness promoted every bit a cure for cancer. At that time, i of the brightest, most highly educated, human I e'er knew decided to pass $300 a calendar month to acquire the Shark pulverisation for his wife.
His logic seemed audio to me. His married adult woman was terminally sick amongst cancer, in addition to what was the risk? Probably non much.
Of course, this human was hoping beyond promise that shark cartilage would plough out to travel a magical cure for his wife. Sadly, it didn't happen.
Now I tin easily envision good educated, vivid people thinking they volition give Bexarotene a try. After all, Bexarotene is already approved past times the FDA for humans, in addition to the profile of side effects looks decent.
So why not?
Please read these quotes that appeared inward the article, A Sudden Flash of Genius Rudy Tanzi, carefully,
Amyloid-beta poly peptide (Abeta) -- the principal element of the plaques flora inward the brains of Alzheimer’s patients -- may travel a normal role of the innate immune system.
“It agency you lot don’t desire to hitting Abeta amongst a sledgehammer,” Dr. Tanzi said. “It says what nosotros demand is the equivalent of a statin for the encephalon in addition to hence you lot tin dial it downward only non plough it off.”
My point. What if you lot gave Bexarotene to a mortal suffering from Alzheimer's in addition to it erased likewise much plaque?
Some of you lot mightiness travel familiar amongst the cleaning production known every bit the Magic Eraser. The Magic Eraser removes stains similar magic. When I say remove, I hateful gone.
So herein lies a existent peril if you lot determine to give Bexarotene to a existent alive person. You mightiness destroy their brain, or perchance kill them. Now, since humans are already taking the drug to process cutaneous T-cell lymphoma (a type of pare cancer) those risks mightiness non travel high. But, how tin nosotros know?
No i knows correct at i time if Bexarotene volition run inward humans for the handling of Alzheimer's disease. We don't know anything close dosage, frequency, or for how long a mortal mightiness accept the drug for the handling of Alzheimer's.
There is to a greater extent than or less expert news. Influenza A virus subtype H5N1 lawsuit of 12 people volition showtime presently to start out to answer to a greater extent than or less of these questions.
Here is what Dr. Gary Landreth, Professor of Neurosciences, Alzheimer Research Laboratory Case Western Reserve University, School of Medicine, said,
"Don't endeavour this at domicile because nosotros don't know what dose to give, nosotros don't know how oft to give it, in addition to at that spot are a few nuances to its administration. So i shouldn't travel prescribing it off-label."
I volition admit, I am tempted to purchase Bexarotene off-label for my mother, Dotty. I hateful what is the risk? She is almost 96 years old, in addition to inward an advanced phase of Alzheimer's. On the other hand, I must inquire myself, what are the consequences if I impairment or kill her? Those consequences aside, would I travel able to alive amongst myself if I harmed her?
My conclusion. Not for us at this time. Nevertheless, I drib dead along to think close it. I bet you lot are too.
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